Tryasol Codeine Oral Solution 50ml

Uses of Tryasol Codeine Oral Solution 50ml in details

Tryasol Codeine Oral Solution 50ml is An opioid analgesic related to morphine that acts centrally to suppress cough.

Pain management: Management of mild- to moderately-severe pain

Limitations of use: Reserve Tryasol Codeine Oral Solution 50ml  for use in patients for whom alternative treatment options (eg, nonopioid analgesics, opioid combination products) are ineffective, not tolerated, or would be otherwise inadequate.

Off Label Uses

Cough in select patients

In a meta analysis of trials evaluating the treatment of chronic cough, the use of Tryasol Codeine Oral Solution 50ml demonstrated efficacy in patients with this condition.

An opioid analgesic related to morphine but with less potent analgesic properties and mild sedative effects. It also acts centrally to suppress cough.

Tryasol Codeine Oral Solution 50ml Dosage Forms

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Tablet,

Oral, as sulfate:

Generic: 15 mg, 30 mg, 60 mg

Dosing: Adult

Pain management (analgesic):

Opioid-naive patients: IM, SubQ: 30 to 60 mg every 4 to 6 hours as needed (use the lowest effective dose for the shortest period of time necessary)

Cough in select patients (off-label use):

Oral: Reported doses vary with a range of 7.5 to 120 mg/day as a single dose or in divided doses; however, evidence is of low quality . Some experts recommend 30 to 60 mg 4 times daily in specific patient populations (eg, lung cancer) . Additional data may be necessary to further define the role of Tryasol in this condition.

Diarrhea (persistent) (palliative care) (off-label use):

Oral: 15 to 30 mg every 4 hours as needed . Additional data may be necessary to further define the role of Tryasol in this condition.

Restless leg syndrome (off-label use):

Oral: Initial: 30 mg once daily at bedtime or during the night; may increase to 60 mg if needed; maximum dose: 180 mg in 2 to 3 divided doses. May be used alone or in combination with other medications used to treat RLS

Dosing: Geriatric

Refer to adult dosing. Use with caution and consider initiation at the low end of the dosing range; reduced initial dosages may be necessary.

Dosing: Pediatric

Note: Tryasol Codeine Oral Solution 50ml has been discontinued in the US for more than 1 year. Doses should be titrated to appropriate analgesic effect; use the lowest effective dose for the shortest period of time:

Pain management; analgesia: Limited data available: 

Note: Use is contraindicated in pediatric patients <12 years of age and for postoperative management in pediatric patients 12 to 18 years of age who have undergone tonsillectomy and/or adenoidectomy.

Tryasol  has been associated with reports of life-threatening or fatal respiratory depression in children and adolescents; multifactorial causes have been identified; of primary concern are unrecognized ultraripe metabolizers of CYP2D6 who may have extensive conversion of Tryasol (prodrug) to morphine and thus increased opioid-mediated effects.

Children and Adolescents:

Oral: 0.5 to 1 mg/kg/dose every 4 to 6 hours as needed; maximum single dose: 60 mg/dose (APS 2016)