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Omnadren 250 properties
Omnadren 250 is a mixture of testosterone esters, which are slowly absorbed at different rates, which allows maintaining a relatively constant level of testosterone in the blood. The preparation is prescribed at intervals of 4 weeks.
In the blood, almost 98% of testosterone binds to a specific fraction of globulins that binds testosterone and estradiol. Biotransformation occurs in the liver to various 17-ketosteroids, which, after conjugation with glucuronic or sulfuric acid, are excreted in the urine (about 90%).
About 6% of the absorbed preparation is excreted unbound in the feces. T½ of testosterone is 10–100 minutes.
The preparation contains 4 testosterone esters, which have different speed of action. in men, testosterone is necessary for the functioning of the gonads, the formation of the external genital organs, the prostate gland, seminal vesicles, secondary sexual characteristics (male tone of voice, male-pattern hairiness, etc.). in the female body, testosterone acts antagonistically in relation to estrogens. has a positive effect in climacteric disorders.
Indications
In men, hypogonadism, delayed puberty, post-castration syndrome, impotence caused by progesterone deficiency, impaired spermatogenesis.
In women – in exceptional cases with diseases that are accompanied by hyperestrogenism.
Application
The dose is set individually. as a rule, 1 ml of solution is administered intramuscularly to adults after 14 days; upon reaching a therapeutic effect – 1 ml / m after 28 days. the preparation should not be administered intravenously! the duration of treatment is set individually. a decrease in the transparency of the oil solution and the appearance of a flocculent sediment of formations do not indicate the unsuitability of the preparation. the transparency of the solution is restored after heating the ampoule in warm water.
Contraindications
Increased individual sensitivity to the components of the preparation; known or suspected breast or prostate cancer; hypercalcemia, hypercalciuria, liver tumor at the moment or in history.
Side effects of Omnadren 250
Acne, gynecomastia, edema, hypersensitivity reactions (skin-allergic reactions), frequent erections, manifestations of hypercalcemia. in elderly men – excessive sexual arousal, impaired maturation of spermatozoa, increased activity of aminotransferases in the blood, increased libido, fluid retention in the body. in women, with prolonged use of the preparation, symptoms of virilization are possible. pain, itching and hyperemia at the injection site are possible.
Special instructions
Long-term use of the preparation in high doses can cause the development of hepatic purpura, liver neoplasms. the use of the preparation Omnadren 250 as a doping agent can cause serious side effects. the period of pregnancy is an absolute contraindication for use. there are no data on the secretion of testosterone in breast milk. if necessary, treatment with the preparation should stop breastfeeding.
Interactions
Inducers of microsomal liver enzymes (rifampicin, barbiturates, carbamazepine, salicylates, phenylbutazone, phenytoin) can reduce the effectiveness of testosterone. androgenic preparations can lower serum glucose levels and reduce insulin requirements.
Storage conditions
In a dark place at a temperature not exceeding 25 ° C.
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