Nembutal Solution Overview

Nembutal Solution (pentobarbital sodium) is a barbiturate that acts as a depressant, or sedative, used short-term to treat insomnia. Nembutal is also used as an emergency treatment for seizures, and to cause patients to fall asleep for surgery. Nembutal is available in generic form.

What are side effects of Nembutal?

Common side effects of Nembutal include:

• problems with memory or concentration,
• excitement,
• irritability,
• aggression (especially in children or older adults),
• confusion,
• loss of balance or coordination,
• nightmares,
• nausea,
• vomiting,
• constipation,
• headache,
• drowsiness,
• “hangover” effect (drowsiness the day after a dose),
• agitation,
• nervousness,
• insomnia,
• anxiety,
• dizziness,
• low blood pressure,
• injection site reactions, or
• skin rash.

Seek medical attention immediately if you suffer from any serious side effects of Nembutal such as:

• hallucinations,
• weak or shallow breathing,
• slow heart rate,
• weak pulse, or
• feeling like you might pass out.

DO NOT USE IF MATERIAL HAS PRECIPITATED

Nembutal Solution DESCRIPTION

The barbiturates are nonselective central nervous system depressants which are primarily used as sedative hypnotics and also anticonvulsants in subhypnotic doses. The barbiturates and their sodium salts are subject to control under the Federal Controlled Substances Act (See “Drug Abuse and Dependence” section).

The sodium salts of amobarbital, pentobarbital, phenobarbital, and secobarbital are available as sterile parenteral solutions.

Barbiturates are substituted pyrimidine derivatives in which the basic structure common to these drugs is barbituric acid, a substance which has no central nervous system (CNS) activity. CNS activity is obtained by substituting alkyl, alkenyl, or aryl groups on the pyrimidine ring.

NEMBUTAL Sodium Solution (pentobarbital sodium injection) is a sterile solution for intravenous or intramuscular injection. Each mL contains pentobarbital sodium 50 mg, in a vehicle of propylene glycol, 40%, alcohol, 10% and water for injection, to volume. The pH is adjusted to approximately 9.5 with hydrochloric acid and/or sodium hydroxide.